Intrinsically Disordered Proteins in Chronic Diseases
نویسندگان
چکیده
منابع مشابه
Intrinsically disordered proteins.
Our understanding of protein function has been predominated by the view that proteins need to adopt a defined three dimensional structure to be able to carry out their function. Indeed, crystal structures of numerous proteins have been instrumental in establishing the structure– function paradigm. For example, the structures of numerous enzymes have highlighted the need for particular chemical ...
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In the same way that neither a messy lab bench nor a clean one is a reliable indicator of a researcher’s productivity, a protein’s function cannot be judged solely on the basis of its neatly folded and stable domains. As evidenced by recent work discussed in this Select, we are learning that intrinsically disordered regions feature in many of the cell’s most productive multitaskers, proteins wh...
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Intrinsically disordered proteins (IDPs) have the potential to play a unique role in the study of proteins and the relationships between structure and function. Intrinsic disorder affects chemical and cellular events such as cell signaling, macromolecular self-assembly, protein removal and crystal nucleation and growth. This chapter explores the structural principles by which IDPs act and revea...
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"What's in a name? That which we call a rose By any other name would smell as sweet." From "Romeo and Juliet", William Shakespeare (1594) This article opens a series of publications on disambiguation of the basic terms used in the field of intrinsically disordered proteins. We start from the beginning, namely from the explanation of what the expression "intrinsically disordered protein" actuall...
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Intrinsically disordered proteins (IDPs) form a unique protein category characterized by the absence of a well-defined structure and by remarkable conformational flexibility. Electron Paramagnetic Resonance (EPR) spectroscopy combined with site-directed spin labeling (SDSL) is amongst the most suitable methods to unravel their structure and dynamics. This review summarizes the tremendous method...
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ژورنال
عنوان ژورنال: Biomolecules
سال: 2019
ISSN: 2218-273X
DOI: 10.3390/biom9040147